Quality Control of mRNA Function
نویسندگان
چکیده
منابع مشابه
Quality Control of mRNA Function
be coupled to each other as well, a feat also thought to Most eukaryotic cellular proteins are generated by transbe orchestrated by the CTD as an additional measure lation of mRNAs that have successfully passed a number of QC. Efficient capping enhances both splicing and 39 of steps to insure their quality. Transcripts that fail to end formation, and efficient 39 end formation enhances pass sel...
متن کاملQuality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.
Cells routinely make mistakes. Some mistakes are encoded by the genome and may manifest as inherited or acquired diseases. Other mistakes occur because metabolic processes can be intrinsically inefficient or inaccurate. Consequently, cells have developed mechanisms to minimize the damage that would result if mistakes went unchecked. Here, we provide an overview of three quality control mechanis...
متن کاملmRNA quality control goes transcriptional
Eukaryotic mRNAs are extensively processed to generate functional transcripts, which are 5' capped, spliced and 3' polyadenylated. Accumulation of unprocessed (aberrant) mRNAs can be deleterious for the cell, hence processing fidelity is closely monitored by QC (quality control) mechanisms that identify erroneous transcripts and initiate their selective removal. Nucleases including Xrn2/Rat1 an...
متن کاملLinks between mRNA splicing, mRNA quality control, and intellectual disability.
In recent years, the impairment of RNA binding proteins that play key roles in the post-transcriptional regulation of gene expression has been linked to numerous neurological diseases. These RNA binding proteins perform critical mRNA processing steps in the nucleus, including splicing, polyadenylation, and export. In many cases, these RNA binding proteins are ubiquitously expressed raising key ...
متن کاملStructure and Function of Pre-mRNA 5′-End Capping Quality Control and 3′-End Processing
Messenger RNA precursors (pre-mRNAs) are produced as the nascent transcripts of RNA polymerase II (Pol II) in eukaryotes and must undergo extensive maturational processing, including 5'-end capping, splicing, and 3'-end cleavage and polyadenylation. This review will summarize the structural and functional information reported over the past few years on the large machinery required for the 3'-en...
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ژورنال
عنوان ژورنال: Cell
سال: 2001
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(01)00202-1